Advance on the association of drug-induced liver injury and HLA gene polymorphism / 中国药学杂志

ABSTRACT

OBJECTIVE: To review and summarize the progress in the genetic association studies between human leucocyte antigen (HLA) polymorphisms and drug-induced liver injury(DILI). METHODS: Based on the literature research, the results of the studies on the association between HLA alleles and DILI are presented and evaluated. RESULTS AND CONCLUSION: Several strong genetic associations between DILI and HLA alleles were observed in previous studies, such as HLA-B*5701 has a strong association with flucloxacillin induced liver injury (odds ratio=80.6). Due to the racial differences in HLA alleles frequency, the incidence of DILI by nevirapine, ticlopidine, ximelagatran varied largely in different ethnic populations. These studies can help us better understand the immunogenic pathogenesis in the underlying mechanism of DILI. The discovery of genetic biomarkers can be developed as a predictive test will improve drug safety and facilitate the individual therapy.