Theoretical analysis and experimental research of pharmaceutical powder compression characteristics base on the Heckel equation / 中国药学杂志

ABSTRACT

OBJECTIVE: To built a general theoretical prediction model of pharmaceutical powder mixtures with different components and mass fraction base on powder compaction Heckel equation. METHODS: Uniaxial compression tests were conducted with four excipients, and the Heckel equation parameters were got. The uniaxial compression tests of mixtures with different mass fraction were conducted; the change laws of density and porosity with applied pressure and the Heckel equation curves were obtained. RESULTS: The comparison of theoretical prediction model and experimental results showed that the porosity error and the Heckel vertical coordinate error were less than 4% and the density error was less than 2.5%. CONCLUSION: The established model has universality to predict the compression characteristics of multicomponent powders of any proportion composition.