Research on impurity of pentoxifylline and glucose injection / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 773-775, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-859749
ABSTRACT
OBJECTIVE:
To study the impurity of pentoxifylline and glucose injection and confirm its structure and source.METHODS:
LC-MS was used to speculate the structure of the impurity. The impurity was synthesized by using theobromine and 1, 3-di-bromopropane as the starting materials and the structure was identified by IR, LC-MS, 1H-NMR, and 13C-NMR.RESULTS:
The impurity was identified to be 1, 1′-(propane-1, 3-diyl)bis(3, 7-dimethyl-3, 7-dihydro-1H-purine-2, 6-dione).CONCLUSION:
The study provides theoretical basis for the control of impurity in the production process and quality assessment of pentoxifylline and glucose injection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2014
Tipo de documento:
Artigo
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