Anti-methicillin-resistant Staphylococcus aureus activities of three main components of azalomycin F / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 644-648, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-859758
ABSTRACT
OBJECTIVE:
To research the anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activities of azalomycins F5a, F4a and F3a and their potential synergistic anti-MRSA activities combined with other compounds.METHODS:
Against a reference strain MRSA ATCC 33592 and eight clinical isolates MRSA 01-08, the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of three main components of azalomycin F were determined by broth microdilution method, and daptomycin was used as positive control. The anti-MRSA effects of them combined with carnosic acid or trimethylhydroquinone were designed with checkerboard method, and determined by broth microdilution method.RESULTS:
Their MICs of azalomycins F5a, F4a and F3a against all nine MRSA strains were successively 4-8, 4 and 4-8 μg · mL-1, and all their MBCs were 8-16 μg · mL-1. All the fractional inhibitory concentration indices (FICIs) of them combined with carnosic acid or trimethylhydroquinone were 0.75-1.25 (indifference) or 0.25-0.50 (synergism).CONCLUSION:
Three main compounds of azalomycin F have remarkable anti-MRSA activities, and the anti-MRSA effect of azalomycins F5a, F4a or F3a combined with trimethylhydroquinone was synergistic. As new anti-MRSA macrocyclide, azalomycin F is worthy of further research and development.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2014
Tipo de documento:
Artigo
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