Effects of Jianpisanjie pills on the gastro-intestinal functions / 中国药学杂志

ABSTRACT

OBJECTIVE: To investigate the effects of Jianpisanjie (JPSJ) pills on the gastro-intestinal functions by animal experiment. METHODS: With gastric evacuation and gastrointestinal propulsion movement of mice obstructed by atropine sulphate, and the emesis of pigeon resulted by copper sulfate, the effects of JPSJ on gastrointestinal function was investigated, the effects on vomit latent period and emesis times were also studied. The model of hepatoma H22 bearing mice was established. After weighting, the mice were randomized into 5 groups, they were the control group, the high, middle, low dosages of JPSJ, and the positive-control group. Then they were treated with chemotherapy and administrated with subject drugs. When the trial ended, the weight and food intake of H22 bearing tumor were determined. RESULTS: Different dosage of JPSJ could increase the gastric evacuation rate and gastrointestinal propulsion rate, prolong the vomit latent period and emesis times of pigeon. And the pills also could reduce the side-effects of chemotherapy, such as weight of mice and food intake. CONCLUSION: JPSJ could promote the gastro-intestinal function, improve the weight loss and less food intake resulted by chemotherapy, and may be adjuvant drug for tumor.