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Application of central composite design in optimization of the formulation of aspirin ointment / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 578-582, 2014.
Artigo em Chinês | WPRIM | ID: wpr-859781
ABSTRACT

OBJECTIVE:

To optimize the formulation of aspirin ointment.

METHODS:

With cumulative permeation quantity within 6 h and shin irritation as indexes, the method of central composite design was used to optimize the formulation of aspirin ointment, taking the most important three ingredients including sodium lauryl sulfale(X1), sodium citrate (X2) and triethanolamine (X3) as the study subjects.

RESULTS:

The optimized formulation of aspirin ointment was composed of 1.41% sodium lauryl sulfate, 3.5% sodium citrate and 3.0% triethanolamine. Three batches of aspirin ointment were prepared using the optimized formulation, for which the average cumulative permeation quantity within 6 h was 990.18 μg · cm-2, and no obvious shin irritation was observed.

CONCLUSION:

Central composite design is successfully used lo optimize the formulation of aspirin ointment.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2014 Tipo de documento: Artigo