Preparation of osteogenic growth peptide nasal spray / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 210-215, 2014.
Article
em Zh
| WPRIM
| ID: wpr-859853
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To prepare osteogenic growth peptide(OGP) nasal spray and investigate the absorption characteristics. METHODS: The absorption enhancer was selected by orthogonal experiment, using the declining quantity of osteogenic growth peptide in rat nose as evalution index with rat nasal perfusion model, and further the dose of protease inhibitor was selected. Finally, the acceletated and long term test were made to investigate the stability of osteogenic growth peptide nasal spray according to Chinese Pharmacopoeia 2010. The rat nasal mucosal shape were inspected by electron microscope after perfusion of osteogenic growth peptide nasal spray. RESULTS: The optimal prescription of osteogenic growth peptide nasal spray is composed of osteogenic growth peptide 2 mg, citric acid 50 mg, HP-β-CD 100 mg, Tween-80 300 mg, and bacitracin zinc 50 mg in 10 mL patossium hydrogen phthalate buffer (pH 3.0). Osteogenic growth peptide nasal spray is much lower irritation to the nasal mucosa cilium. CONCLUSION: The stablity of osteogenic growth peptide nasal spray was good, safe and had very good absorption in rat nose.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2014
Tipo de documento:
Article