Efficacy and safety of benidipine in patients with mild- to- moderate hypertension, a multicenter double-blind randomized controlled clinical trial / 中国药学杂志

ABSTRACT

METHODS: With random and double-blinded method in multicenters, 201 eligible patients aged from 18 to 75 years with mild to moderate hypertension were devided into two groups after received placebo for 2 weeks, 99 patients in experimental group received benidipine 2 mg once a day, 102 patients in control group were given lacidipine 4 mg, once a day for 4 weeks. The dose is adjusted after 4 weeks in the patients not reaching the blood pressure target of DBP or SBP. The whole treatment was continued for 8 weeks, patients must finish one visit every 2 weeks for observing efficacy and adverse events.