Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
Kidney Research and Clinical Practice
;
: 222-225, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-86001
ABSTRACT
Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (>50%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement after intravenous immunoglobulin-G therapy. Owing to the rapid, fatal course of TEN, clinicians need to be aware of the adverse effects of this drug when treating cases of NS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Pele
/
Enalapril
/
Síndrome de Stevens-Johnson
/
Extremidade Inferior
/
Epiderme
/
Unidades de Terapia Intensiva
/
Necrose
/
Síndrome Nefrótica
Limite:
Adolescente
/
Criança, pré-escolar
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2014
Tipo de documento:
Artigo
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