Progress in research of biorelevant dissolution media / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2084-2088, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-860107
ABSTRACT
OBJECTIVE:
To summarize and analyze the physiological parameters of the gastrointestinal tract, as well as the progress in research of biorelevant dissolution media.METHODS:
Related literatures in recent years were reviewed.RESULTS:
The biorelevant dissolution media based on physiological relevant information were used to establish the methods of dissolution evaluation in vitro.CONCLUSION:
With depth understanding of the physiological parameters of the gastrointestinal tract, in vitro dissolution of dosage form in biorelevant dissolution media could predict in vivo dissolution performance. In addition, biorelevant media were utilized to investigate the food effect on dissolution. Therefore, the liability of evaluating in vitro-in vivo correlation is further improved.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2014
Tipo de documento:
Artigo
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