Development of the novel cationic nanoemulsion drug delivery system / 中国药学杂志

ABSTRACT

OBJECTIVE: To review the development of the novel cationic nanoemulsion drug delivery system. METHODS: Making a comparison between nanoemulsion and cationic nanoemulsion on the basis of a decade of research literatures, then describing the application status and the key technical problem of this novel drug delivery system in detail. RESULTS AND CONCLUSION: Cationic nanoemusion was mainly by electrostatic and muco-adhensive approaches to promote the absorption and bioavailability of drugs. It's designed to improve the solubility of poorly soluble drugs and the permeability of nucleic and protein drugs. Nowadays, as ideal novel drug delivery system with the advantages of simple preparation and having the characters of good stability and safety, cationic nanoemusion was recently a promising alternative formulation approach for delivery of drug by oral, mucosal and transdermal drug delivery systems.