Progress in dipeptidyl peptidase-4 and its inhibitors / 中国药学杂志

ABSTRACT

OBJECTIVE: To review the structures of dipeptidyl peptidase-4 (DPP-4) and its inhibitors and introduce the evaluation methods of several marketed inhibitors. METHODS: Preparation of this review is based on searching, categorizing, analyzing and summarizing of diplomatic and international literatures about DPP-4 and its inhibitors. RESULTS AND CONCLUSION: DPP-4 has attracted a lot of attention as a new target of type 2 diabetes, and some drug candidates have been developed and entered clinical phases. The structure-activity relationship study of various reported inhibitors could promote the development of more efficient DPP-4 inhibitors.