Progress of studies on protective mechanism of Radix Astragali in vascular endothelial cells / 中国药学杂志

ABSTRACT

OBJECTIVE: To review the progress of studies on protective mechanism of Radix Astragali in vascular endothelial cells. METHODS: The summarization of the progress of studies on protective mechanism of tonifying qi chinese medicine Radix Astragali as well as its effective components in vascular endothelial cells were based on referring to the related literature in recent years. RESULTS: The protective function of Radix Astragali as well as its effective components in vascular endothelial cells in means of promoting endothelial cells proliferation, inhibiting cells apoptosis, promoting angiogenesis, boosting nitric oxide composition, intervening cells adhesion, ameliorating vasodilatation function, regulating endothelial active substance secretion, antioxidation and so on, revealed significance therapeutic value in cardiovascular diseases and other diseases with endothelum disfunction. CONCLUSION: Because of the multiple-targeted protective effect of Radix Astragali in vascular endothelial cells, the summarization of the protective mechanism and character of Radix Astragali in vascular endothelial cells had possessed of vital theoretical value with regard to exploring "tonifying qi" effective of Radix Astragali in prevention and treatment of blood stasis.