Preparation of paclitaxel-loaded mixed micelles and its in situ absorption in rat intestine / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1076-1082, 2013.
Article
em Zh
| WPRIM
| ID: wpr-860330
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To study the oral absorption of paclitaxel-loaded mixed micelles made of D-α-tocopherol polyethylene glycol 1000 succinate(TPGS) and sodium cholate(NaC) in rats. METHODS: Paclitaxel-loaded mixed micelles were prepared by film dispersion method. The Zeta potential and diameter distribution of TPGS/NaC mixed micelles were measured using laser size scattering determinator. The morphology of micelles was observed by transmission electron microscope. Dialysis method was used to evaluate the release behavior of drug-loaded micelles in vitro. The absorption kinetics was obtained by in situ perfusion method in rats. RESULTS: Most of the mixed micelles were spherical with an average diameter of 24.2 nm and the Zeta potential was -7.84 mV. Compared to the bulk drug, the apparent absorption rate constant (Ka)of paclitaxel-loaded mixed micelles was increased significantly. CONCLUSION: TPGS/NaC mixed micelles can improve the oral absorption of paclitaxel and increase its oral bioavailability.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2013
Tipo de documento:
Article