Synthesis of arachidic acid-cholic acid conjugate aramchol for treating disordered lipid metabolism / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 920-924, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-860373
ABSTRACT
OBJECTIVE:
To optimize the process of synthesizing aramchol.METHODS:
Using arachidic acid (eicosanoic acid) and cholic acid as the starting materials, 3β-arachidyl-amido-7α, 12α-dihydroxyl-5β-cholanic-24-acid, a fatty acid bile acid conjugate aramchol, was synthesized through a 9 step route in which the carboxyl group and hydroxyl groups of cholic acid has been orthogonally protected and regioselectively deprotected.RESULTS:
The yield of the target product was 12.7%.CONCLUSION:
With reproducibile reactions, less by-products, and mild, controllable and relatively safe conditions, the improved process is very suitable for lab-scale production.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
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