Analysis of the improvement of perioperative antibiotic prophylaxis in our hospital / 中国药学杂志

ABSTRACT

OBJECTIVE: To analysis the improvement of perioperative antibiotic prophylaxis in 3 kinds of surgical incisions after we strengthened the management of antibiotics in our hospital and provide reference for clinical rational use of antibiotics. METHODS: Random selected 139 medical records from January to October in 2011as the control group, and random selected 150 medical records from January to October in 2012 as the monitoring group. Compared the surgical site infection rates, antimicrobial utilization rate, the average number of medication days, the cost of antimicrobial drugs and the rationality of the antibiotics, etc. between the two groups in order to investigate if the monitoring group significantly improved. RESULTS: There was no significant difference (p=1.00) in Surgical site infection rates between the two groups. The antimicrobial utilization rate (P<0.001), the average number of medication days (P=0.001), the average cost of hospitalization (P=0.006), the average drug costs (P<0.001), the average antibacterial drug costs (P<0.001), the average antibacterial drug cost/the average cost of hospitalization (P<0.001), the reasonable rate for the choice of the drug (P=0.003), the reasonable rate for the intraoperative medication time (P=0.007) in the monitoring group were significantly better than the control group in type 1incision operation; in type 2incision operation the average number of medication days (P=0.05), the average antibacterial drug costs (P=0.015), the average antibacterial drug costs/the average inpatient costs (P=0.03), the reasonable rate for the preoperative medication time (P<0.001), thereasonable rate for the postoperative medication (P=0.001) in the monitoring group were significantly better than the control group; and in type 3 incision operation only the average antibacterial drug costs/the average inpatient costs (P=0.046) and the reasonable rate for the intraoperative medication time (P=0.057) in the monitoring group were significantly better than the control group. COMCLUSION The Measures to strengthen the management of antimicrobial drugs in our hospital can improve the rational use of antimicrobial agents in type 1incision operation. However, we need to further strengthen the management of preventive antibacterial drugs in type 2and type 3 incision operation.