Preparation of testosterone hot melt pressure sensitive adhesive transdermal patch / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare testosterone hot melt pressure sensitive adhesive (HMPSA) transdermal patch and investigate its percutaneous permeability in vitro. METHODS: The matrix of thermoplastic elastomer styrene-isoprene-styrene(SIS) hot melt pressure sensitive adhesive was used for testosterone transdermal patch. The percutaneous permeability through excised nude mice skin or porcine skin in vitro was conducted by Franz diffusion cells. Cumulative permeation quantity (Q) and steady state permeation rate (Jss) were evaluated to optimize drug loading capacity and enhancer. The optimal transdermal patches were compared with reference patches with regard to percutaneous behaviors using excised nude mice skin and porcine skin. RESULTS: The optimal formulation contained 2% testosterone, 6% transdermal enhancer isopropyl myristate(IPM). Its permeation behavior in vitro followed zero-order kinetics. The permeation behavior of the optimal patches was better than the reference patches for excised nude mice skin and porcine skin. CONCLUSION: SIS HMPSA has a broad application potential for transdermal drug delivery system.