Determination of foscarnet sodium injection and its related substance by ion chromatography / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1658-1660, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-860596
ABSTRACT
OBJECTIVE:
To establish a gradient ion chromatography method to determine the content of foscarnet sodium injection and its related substances.METHODS:
The separation was performed on an Ionpac AG18 (4 mm×50 mm, 13 μm) + AS18 column (4.0 mm×250 mm, 7.5 μm) using potassium hydroxide produced by eluent generator (EG) as the mobile phase at a flow rate of 1 mL · min-1. Suppressed conductivity detection was adtopted. The column temperature was maintained at 30°C.RESULTS:
The calibration curve of foscarnet sodium was linear between 2-100 μg · mL-1 (r=0.9998), and the calibration curves of the related substances were linear between 0.05-2 μg · mL-1 (r=0.9999 and r=0.9998). The intra-day and inter-day RSDs of foscarnet sodium were 0.35% (n=5) and 0.41% (n=5), respectively. The average recovery was 101%.CONCLUSION:
The method is specific, sensitive and can be applied to determine the content and impurities of foscarent sodium injection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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