Effects of fructopyrano-(1 → 4)-glucopyranose extracted from Radix Isatidis on tumor growth and immune function in tumor-bearing mice / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the effects of fructopyrano-(1 → 4)-glucopyranose (FG) extracted from Radix Isatidis on the tumor growth and immune activity in tumor-bearing mice. METHODS: The antitumor activity of FG in vivo was observed by implanted H22 and S180 mouse models. The effect of FG on immune function in tumor-bearing mice was investigated by using phagocytosis test, T plymphocyte proliferation test, and Elisa for determining the expression levels of TNF-α, IL-2, IL-6, and IL-12. RESULTS: At dosages of 50, 100 and 200 mg · kg-1, the inhibition rates of FG were 23.60%, 36.76% and 49.26% for S180, 22.61%, 36.52%, and 46.95% for H22, respectively. FG increased the spleen index and chest gland index, improved the phagocytosis function of the macrophage and enhance the T lymphocytes proliferation, and increased the expression levels of TNF-α, IL-2, IL-6, and IL-12. CONCLUSION: FG exhibits significant anti-tumor effect in vivo and the mechanism may be related to enhancing immune function. Copyright 2012 by the Chinese Pharmaceutical Association.