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The effect of AICAR on rat uterine smooth muscle / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 847-851, 2012.
Artigo em Chinês | WPRIM | ID: wpr-860712
ABSTRACT

OBJECTIVE:

To study the effect of AICAR on uterine smooth muscle of pregnant and nonpregnant rats.

METHODS:

The action of AICAR and dibutyryl-cAMP on the contractile function of isolated myometrium of pregnant and nonpregnant Sprague-Dawley rats was investigated. AICAR or dibutyryl-cAMP was used at cumulative doses from 10-9 to 10-4 mol · L-1 for myometrium of pregnant rats, and at 10-5 mol · L for myometrium of nonpregnant rats. The amplitude of the contractility of myometruim was recorded.

RESULTS:

For the myometrium of pregnant or nonpregnant rats, AICAR and dibutyryl-cAMP exerted strong inhibitory action on the contractile function in dose-dependent manners. For the myometrium of pregnant rats, AICAR or dibutyryl-cAMP showed inhibitory effect at a low concentration of 10-7 mol · L-1. AICAR and dibutyryl-cAMP also caused significant inhibition in myometrium from nonpregnant rats.

CONCLUSION:

AICAR exerted strong inhibitory action on the contractile function of myometrium from pregnant or nonpregnant rats, suggesting that AICAR may have inhibitory effect on spontaneous activity of myometrium of human.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Pharmaceutical Journal Ano de publicação: 2012 Tipo de documento: Artigo