Determination of chromium in soft capsule shells by microwave digestion-graphite furnace atomic absorption spectrophotometry / 中国药学杂志

ABSTRACT

OBJECTIVE: To establish a method of microwave digestion-graphite furnace atomic absorption spectrophotometry for the determination of chromium in soft capsule shells. METHODS: Microwave digestion was adopted to digest the soft capsule shells. Graphite furnace temperature control program was optimized, zeeman effect was used in the background correction, the slit width was 0.5 nm, and the content of chromium was determined under the wavelength of 357.9 nm. RESULTS: The calibration curve was linear in the range of 0-50 mg·L-1 (r=0.9996). The detection limit was 0.06 mg·kg-1, and the average recoveries were 90%-110%. CONCLUSION: This method is simple, accurate, and suitable for the determination of chromium in soft capsule shells. Copyright 2012 by the Chinese Pharmaceutical Association.