Study on cytochrome P450 2C19 (CYP2C19) genetic polymorphism in Qinghai Sala population / 中国药学杂志

ABSTRACT

OBJECTIVE: To identify the genotype and allele distribution feature of cytochrome P450 2C19( CYP2C19) in Qinghai Sala population. METHODS: The CYP2C19 genotypes of 99 healthy Sala population were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology. RESULTS: In Qinghai Sala population, CYP2C19 * 1, CYP2C19 * 2 and CYP2C19 * 3 allele frequencies were 56.6%, 29.8% and 13.6%, respectively; CYP2C19 * 1/ * 1, CYP2C19 * 1/ * 2, CYP2C19 * 1/ * 3, CYP2C19 * 2/ * 2 and CYP2C19 * 2/ * 3 genotype frequencies were 30.3%, 36.4%, 16.2%, 6.1% and 11.1%, respectively; CYP2C19 * 3 / * 3 homozygous genotype was not found in this study. CONCLUSION: The genotype distribution of CYP2C19 in Qinghai Sala population is significantly different to Uigu, Li, Bai, Dai, She, Hui and Iran population, but similar to Tu, Du-long, Miao, Zang and Han population. Copyright 2012 by the Chinese Pharmaceutical Association.