Analysis of plasticizer in compound aluminum hydroxide tablets with GC-MS/MS / 中国药学杂志

ABSTRACT

OBJECTIVE: To develop GC/MS method in detect plasticizers in compound aluminum hydroxide tablets adsorbed from pharmaceutical packaging. METHODS: The column HP-5MS silica capillary column (30 m × 0.25 μm, 0.25 mm) was used; Ion source temperature was 230°C; Quadrupole temperature was 150°C; The total ion scanning rang m/z 50~500. RESULTS: The diethylhexyl phthafate linearity was in the range of 0.5 -20.0 μg · mL-1 with a regression coefficient of 0.9990. The average recovery of this method was 98.8%, and RSD was 1.4%. The RSD of intra-day and inter-day was 2.8% and 3.1% respectively. CONCLUSION: This method is specificity, sensitive, and can be applied to detect and research DEHP which may be adsorbed or penetrated into drugs. Copyright 2012 by the Chinese Pharmaceutical Association.