Effects of Tongxinluo capsule on platelet activity and vascular endothelium function at different stages in patients with acute coronary syndrome undergoing percutaneous coronary intervention / 中国药学杂志

ABSTRACT

OBJECTIVE: To observe the effects of Tongxinluo capsule on platelet activity and function of vascular endothelium at different stages after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome. METHODS: One hundred and sixty patients with acute coronary syndrome were randomly divided into Tongxinluo (TXL) treatment group (TXL group, 80 patients) and conventional treatment group (conventional group, 80 patients). Fifty healthy people were enrolled as control group. The blood levels of CD62p, CD63, glucose protein (GP) II b/III a and endothelium 1 (ET-1), vWF, nitric oxide(NO), and flow-mediated dilatation (FMD) in brachial artery were examined before PCI and the second day after PCI in both groups. Then the patients in TXL group received TXL treatment for 6 months (4 capsule tid), and the above parameters were compared with those of conventional treatment group. RESULTS: The ACS patients' blood levels ofCD62p, CD63, GP II b/III a, vWF and ET-1 increased significantly (P < 0.01), NO and FMD decreased significantly (P < 0.01), compared with control group. The ACS patients' plasma levels of vWF increased significantly (P < 0.05), CD62p, CD63, GP II b/III a and FMD decreased significantly (P < 0.05) after PCI compared with baseline levels. In both TXL group and conventional group, the patients' plasma levels of CD62p, CD63, GP II b/III a, vWF and ET-1 decreased significantly (P < 0.05, P < 0.01) FMD increased significantly (P < 0.05, P < 0.01) compared with baseline levels, meanwhile there were significant differences in all the parameters between TXL group and conventional group (P < 0.01, P < 0.05). In addition, the parameters showed significant differences between 6 months and 2 months after TXL treatment (P < 0.01, P < 0.05). CONCLUSION: TXL can inhibit platelet activity and protect the vascular endothelium function after PCI. Copyright 2012 by the Chinese Pharmaceutical Association.