Shear wave elastography and γ-glutamyl transpeptidase/platelet ratio in diagnosis of liver fibrosis in chronic hepatitis B patients / 中国医学影像技术

ABSTRACT

Objective: To explore the application value of shear wave elastography (SWE) and γ-glutamyl transpeptidase/platelet ratio (GPR) in diagnosis of liver fibrosis in chronic hepatitis B (CHB) patients. Methods: A total of 116 patients with CHB were collected. SWE examinations and blood routine and liver function tests were performed before liver biopsy. Liver hardness measurement (LSM) was recorded, and GPR was calculated. According to the Metavir scoring system, liver fibrosis was classified as F0, F1, F2, F3 and F4 in the pathologic examinations. The correlations of SWE, GPR and liver fibrosis stages were analyzed. Receiver operating characteristic curve (ROC) was drawn, and Elast PQ and GPR for diagnosis of liver fibrosis in patients with CHB were compared. The diagnostic value of Elast PQ of liver fibrosis in patients with ALT below 2 times of the upper limit of normal (ULN) value was analyzed. Results: Elast PQ and GPR were all positively correlated with liver fibrosis staging (r=0.94, P<0.01; r=0.92, P<0.01). The diagnostic efficiency of Elast PQ was superior to that of GPR for F1-F3 fibrosis stages (Z=2.21, P=0.03; Z=2.16, P=0.03; Z=2.27, P=0.02), of Elast PQ in patients with ALT≤1×ULN was better than that in patients with 1×ULNConclusion: Both Elast PQ and GPR had good diagnostic value for staging of liver fibrosis in patients with ALT≤2×ULN, and Elast PQ was better than GPR.