Correlation of CT enhancement degree and pathology of resectable pancreatic ductal adenocarcinoma / 中国医学影像技术

ABSTRACT

Objective: To analyze the correlation of CT enhancement degree and pathology of pancreatic ductal adenocarcinoma (PDAC), and to observe its value for prognostic assessment. Methods: Data of 150 patients with PDAC confirmed by pathology were retrospectively analyzed. All patients underwent preoperative CT plain scanning and double period (parenchymal phase and portal phase) enhanced scanning of pancreas. The CT value difference of PDAC and peripheral pancreatic parenchyma (parenchymal phase and portal phase CTpancreas-tumor), as well as that of tumor enhancement and plain scan (CTparenchymal phase-plain phase, CTportal phase-plain phase) were measured. Correlation of all CT value differences and pathological differentiation or content of fibrous stroma within PDAC were observed, and the independent impact factors of survival time of PDAC patients were analyzed. Results: There was a moderate correlation between parenchymal phase CTpancreas-tumor and pathological differentiation but low correlation among the remaining CT value differences and pathological differentiation of PDAC (all P<0.05). Parenchymal phase CTpancreas-tumor was negatively correlated with content of fibrous stroma (r=-0.51, P<0.05). Tumor differentiation, lymph node metastasis and surgical margin status were independent risk factors of survival time of PDAC patients (all P<0.05). Conclusion: Parenchymal phase CTpancreas-tumor of PDAC was negatively correlated with pathological differentiation and content of fibrous stroma. The smaller CT value difference indicates, the lower pathological staging and the longer survival time were.