Application of oral administration of diamine diluent before magnetic resonance cholangiopancreatography in children / 中国医学影像技术

ABSTRACT

Objective: To observe the feasibility of oral administration of diluted gadolinium diamine injection as negative contrast agent for gastrointestinal tract for improving imaging quality and displaying pancreaticobiliary duct during magnetic resonance cholangiopancreatography (MRCP) in children. Methods: MRI of gadolinium diamine diluent with concentrations of 0.20%, 0.30% and 0.50% and pure water were performed at the same time, then the signal attenuation rate of each concentration of contrast agent was calculated. A total of 282 children received MRCP were divided into experimental group (244 children with suspected hepatobiliary diseases) and control group (38 children with non-hepatobiliary diseases). One hour before examination, children in experimental group were asked to orally take 0.50% gadolinium diamine diluent 400 ml within 45 min, and then underwent MRCP 15 min later. All images were scored by 2 imaging physicians, and the imaging qualified rate of was calculated taken ≥3 points and not affecting diagnosis as qualified standards. Kappa coefficient was used to test the consistency of image quality assessments of 2 doctors, and the differences of imaging qualified rate were compared between 2 groups and different genders. Results: The signal attenuation rate of the concentration of 0.20%, 0.30% and 0.50% gadolinium diamine diluents was 76.67%, 88.47% and 98.33%, respectively. The 0.50% gadolinium diamine diluent had the best water inhibition effect, and was selected as the negative contrast agent for children gastrointestinal tract. The consistency of Results: of imaging quality scores by 2 doctors was good (Kappa=0.85, P0.05). Conclusion: Oral administration of 0.5% concentration of gadolinium diamine diluent can effectively inhibit high gastrointestinal fluid signals and significantly improve imaging quality of MRCP in children.