Amplitude of low-frequency fluctuation in resting-state spontaneous brain activity in children with idiopathic epilepsy / 中国医学影像技术

ABSTRACT

Objective: To explore the features of the amplitude of low-frequency fluctuation (ALFF) in resting-state brain activity in children with idiopathic epilepsy (IE). Methods Totally 17 children with IE (IE group) and 14 matched controls (control group) were recruited. The structural and resting-state fMRI data were collected, and ALFF was computed with DPARSF software. The difference of ALFF between 2 groups was explored with the multivariate regression model, and the age and gender were considered as covariates. The correlation between ALFF and duration of disease was evaluated. Results Compared with control group, increased ALFF brain regions were observed in right brainstem, left cerebellum and parahippocampus in IE group, and reduced ALFF brain regions were observed in bilateral anterior cingulate gyrus, bilateral orbital frontal cortex, left superior frontal gyrus, left middle frontal gyrus, bilateral parietal lobule and bilateral angular gyrus (all P<0.05, 3dClustSim corrected). The multivariate regression analysis showed that ALFF in the right brainstem was positively correlated with the duration of IE (r=0.82, P<0.05, 3dClustSim corrected). Conclusion: The spontaneous brain activity in children with IE alters and associates with duration of disease. These findings may be evidences for elucidating potential neural mechanism of IE in childhood.