Research progress on the correlation between ferroptosis and breast cancer / 中国肿瘤临床

ABSTRACT

Ferroptosis, a recently discovered form of programmed cell death characterized by iron-dependent accumulation of lipid reactive oxygen species, plays an important role in diseases such as breast cancer. Although breast cancer is a common malignant tumor in women, its etiology and pathogenesis remain unclear. However, activation of the ferroptosis pathway is known to affect breast cancer cells by inhibiting their proliferation, mitigating their resistance to chemotherapy drugs, enhancing their sensitivity to radiotherapy, and inhibiting their distant metastases; thus, the ferroptosis pathway is a potential novel target for the treatment of breast cancer. Herein, we summarize the mechanisms of ferroptosis and its potential role in breast cancer treatment.