Comparison of Lactulose and Polyethylene Glycol Electrolyte in Bowel Preparation Before Colonoscopy: A Randomized Controlled Single-blind Clinical Study / 胃肠病学

ABSTRACT

Background: Bowel preparation is important for improving the effectiveness and positivity rate of colonoscopy. At present, all laxative drugs used in clinical medicine have certain shortcomings and limitations. Exploring ideal bowel preparation drug has important clinical value. Aims: To compare the effectiveness of lactulose and polyethylene glycol electrolyte in bowel preparation before colonoscopy. Methods: A total of 150 patients underwent colonoscopy from June 2019 to November 2019 at the Second Affiliated Hospital of Baotou Medical College were enrolled and randomly divided into the lactulose group and the polyethylene glycol electrolyte group, and the laxatives were taken in two stages. The patient's basic information, subjective feelings and adverse reactions during bowel preparation, the stool frequency and the last stool consistency were collected. The score of cleanliness and foam of each segments of intestine were estimated. Results: No significant differences in gender, age, BMI, education level, stool consistency and frequency were found between lactulose group and polyethylene glycol electrolyte group. Stool frequency in Stage 1 and the total stool frequency in lactulose group were significantly higher than those in polyethylene glycol electrolyte group (P<0.05), however, cleanliness score of descending colon was significantly lower (P<0.05). The taste score was significantly lower in lactulose group than in polyethylene glycol electrolyte group (P<0.05), and the incidence of thirst was significantly higher in lactulose group (P<0.05). Correlation analysis showed that cleanliness of descending colon, sigmoid colon were negatively correlated with stool frequency in Stage 1 (P<0.05), cleanliness of rectum was negatively correlated with total stool frequency (P<0.05). Conclusions: Lactulose has good application value in bowel preparation before colonoscopy, and its taste is better than polyethylene glycol electrolyte. Evaluating the stool frequency in Stage 1 and total stool frequency can optimize the quality of bowel preparation and enhance the cleanliness of various segments of intestine.