Changes of Uric Acid Metabolism and its Potential Significance in Patients With Crohn's Disease / 胃肠病学

ABSTRACT

In healthy subjects, about 2/3 serum uric acid (UA) was excreted by kidney, and 1/3 by intestine. UA not only has antioxidant effect, yet also promotes oxidation. Crohn's disease (CD), one of the non-specific gastrointestinal inflammatory diseases, is often associated with extraintestinal manifestations and systemic metabolic changes. Abnormal UA metabolism is commonly seen in CD patients, and its significance is not clarified, which brings trouble to clinical treatment. This article reviewed the changes of UA metabolism and its potential significance in patients with CD.