Investigation and Analysis of Familial Aggregation of Helicobacter pylori Infection / 胃肠病学

ABSTRACT

Background: Helicobacter pylori (Hp) infection is an important public health problem, and the transmission mode of Hp is not yet fully understood, however, human-to-human transmission route has been widely recognized, thus familial aggregation may occur for Hp infection. Aims: To explore the Hp infection in family members of Hp-positive patients and to analyze the familial aggregation of Hp infection. Methods: A total of 976 patients who underwent 14C-urea breath test (14C-UBT) from January 2018 to January 2019 were enrolled. According to Hp infection, the subjects were divided into Hp-positive group (case group) and Hp-negative group (control group), and all family members of all the subjects were encouraged to detect Hp infection. The Hp infection of family members in the two groups, the consistence of Hp infection between husband and wife, and the relationship between Hp-positive parents and Hp infection of children in case group were analyzed, and the goodness-of-fit test for binomial distribution was used to explore familial aggregation of Hp infection. Results: Among the 493 complete families who completed the survey, Hp-positivity rate in parents, spouses, children in case group were 70.6%, 62.1%, 65.9%, respectively, and were significantly higher than those in parents, spouses, children in control group (63.2%, 54.4%, 56.7%, respectively) (P0.05). Among 548 children in case group, 361 children were Hp positive, and the infection rate was increased with the increase of parental infection (P<0.05). The goodness-of-fit test showed that there were statistically significant differences in the actual households distribution and theoretical households distribution of Hp infection (P<0.05). Conclusions: There is a certain familial aggregation of Hp infection. When a member of the family is infected, the risk of Hp infection of parents, spouses and children may increase.