Risk Factors of Extraintestinal Manifestations in Ulcerative Colitis / 胃肠病学

ABSTRACT

Background: Ulcerative colitis (UC) is often accompanied by a variety of extraintestinal manifestations (EIM). EIM is important for the diagnosis and treatment of UC. Aims: To investigate the risk factors of EIM in patients with UC. Methods: The clinical data of patients with UC from Jan. 2013 to Dec. 2018 at the People's Hospital of Xinjiang Autonomous Region were retrospectively analyzed. Univariate and multivariate analysis were performed to investigate the risk factors of EIM in UC. Results: A total of 260 UC patients were enrolled, of them 120 (46.2%) had EIM. The main EIM were musculoskeletal manifestation, skin disease, eye disease, hepatobiliary disease. Univariate analysis showed that Uyghur (χ2=4.069, P=0.044), older (χ2=4.250, P=0.039), BMI≥24 kg/m2 (χ2=13.913, P=0.000), history of intestinal surgery (χ2=6.089, P=0.014) and disease activity (χ2=27.556, P=0.000) were associated with EIM in UC patients. Multivariate analysis showed that Uyghur (OR=1.802, P=0.042), BMI≥24 kg/m2 (OR=3.163, P=0.000), history of intestinal surgery (OR=4.089, P=0.042) and disease activity (OR=6.347, P=0.000) were risk factors of EIM in UC patients. Conclusions: Uyghur, BMI≥24 kg/m2, history of intestinal surgery and disease activity are important risk factors of EIM in UC patients.