Three-dimensional speckle tracking imaging in evaluation on left ventricular systolic function of Paclitaxel combined with Carboplatin in patients with ovarian cancer / 中国介入影像与治疗学

ABSTRACT

Objective: To explore the application value of three-dimensional speckle tracking imaging (3D-STI) in evaluation on changes of left ventricular systolic function caused by Paclitaxel combined with Carboplatin for treatment of ovarian cancer. Methods: Thirty patients with pathologically diagnosed ovarian cancer (ovarian cancer group) were selected and treated with Paclitaxel combined with Carboplatin chemotherapy. 3D-STI examination was performed before chemotherapy and at the end of 3 and 6 cycles of chemotherapy to obtain left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV), left ventricular ejection fraction (LVEF), spherical index (SPI), left ventricular end diastolic mass (LVEDmass), left ventricular end systolic mass (LVESmass), left ventricular global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS) and global area strain (GAS), and the indexes compared with those of 30 healthy volunteers (control group). ROC curve was used to analyze the diagnostic efficacy of various strain parameters for cardiac function abnormalities in patients with ovarian cancer after chemotherapy. Results: Compared with control group, LVEDV and LVEF decreased, LVEDmass and LVESmass increased, and left ventricular GLS, GCS, GRS and GAS decreased after 3 and 6 cycles of chemotherapy in ovarian cancer group (all P<0.05). ROC curve of systolic peak strain parameters for diagnosis of cardiac function in patients with ovarian cancer after chemotherapy showed that AUC (0.944) and specificity (96.67%) of GAS were the highest at the end of 3 cycles of chemotherapy while GLS and GCS had the highest sensitivity (90.00%).At the end of 6 cycles of chemotherapy, GAS had the highest AUC (0.953) and specificity (96.67%), and GLS had the highest sensitivity (93.33%). Conclusion: 3D-STI can early detect of left ventricular systolic function in patients with ovarian cancer treated with Paclitaxel combined with Carboplatin.