High-resolution CT combined MR T2-DRIVE sequence imaging in diagnosis of children cochlear nerve dysplasia / 中国介入影像与治疗学

ABSTRACT

Objective: To investigate the value of high-resolution CT (HRCT) combined with MR T2-DRIVE in diagnosis of cochlear nerve dysplasia (CND) of children. Methods: HRCT and MR T2-DRIVE image data of 43 children (28 unilateral and 15 bilateral) with CND were retrospectively analyzed. The diameters of cochlear nerve canal (CNC) and cochlear nerve were measured with HRCT and T2-DRIVE,respectively. The correlation between CNC diameter and cochlear nerve diameter was analyzed by using Spearman correlation. Results: A total of 58 diseased ears, including 27 pure CND ears and 31 CND accompanied with malformation of inner ear ones, as well as 28 normal ears were found among 43 CND children. HRCT showed CNN stenosis in 45 ears, CNC atresia or absence in 13 ears, internal auditory canal stenosis in 15 ears, including CNC stenosis 12 ears, CNC atresia 2 ears and CNN absence 1 ear. MRI showed abnormal facial nerve morphology in 7 ears, vestibular nerve absence in 1 ear and slender in 1 ear. Among 15 ears of internal auditory canal stenosis, vestibulocochlear nerve was absence in 8 ears and slender in 3 ears, while was normal in 4 ears. Among 58 diseased ears, CNC was demonstrated normal on both HRCT and MRI in 7 ears. The diameters of CNC and cochlear nerve of CND ears were all smaller than those of normal ears (both P=0.001), while no statistically difference of diameters of CNC and cochlear nerve between pure CND ears and CND accompanied with malformation of inner ear ones (P=0.185, 0.140). CNC diameter of all 86 ears was positively correlated with diameter of cochlear nerve (rs=0.773, P<0.001). Taken CNC diameter=1.5 mm as cut-off value, the sensitivity, specificity, positive predictive value and negative predictive value for diagnosis of CND was 84.48% (49/58), 100% (28/28), 100% (49/49) and 75.68% (28/37), respectively. Conclusion: HRCT combined with MR T2-DRIVE can provide diagnostic references for CND of children.