Safety and efficacy of modified liquid isolation method in microwave ablation in treatment of secondary hyperparathyroidism / 中国介入影像与治疗学

ABSTRACT

Objective: To observe the safety and efficacy of modified liquid isolation method during ultrasound-guided microwave ablation in treatment of secondary hyperparathyroidism (SHPT). Methods: Clinical data of 82 SHPT patients who underwent ultrasound-guided microwave ablation were retrospectively analyzed. Among them, 41 cases adopted improved liquid isolation method (observation group), while the other 41 cases received traditional liquid isolation method (control group). Unit volume ablation time, serum intact parathyroid hormone (iPTH), iPTH change rate and serum calcium before and 7 days after operation, the incidence and recovery rate of recurrent laryngeal nerve injury during and 6 months after operation were compared between the two groups. Results: There was no significant difference of unit volume ablation time, serum iPTH, iPTH change rate nor serum calcium level before and 7 days after operation between the two groups (all P>0.05). The incidence of recurrent laryngeal nerve injury in observation group during and 6 months after operation was 14.63% (6/41), lower than that of control group (43.90%[18/41], P=0.004). Six months after operation, all 6 patients (6/6, 100%) with recurrent laryngeal nerve injury in observation group and 13 patients (13/18, 72.22%) in control group recovered (P=0.003). Conclusion: Modified liquid isolation microwave ablation can effectively treat SHPT and reduce recurrent laryngeal nerve injury.