Comparison of cyclic and linear gadolinium chelates for enhancement MRI of prostate hyperplasia / 中国介入影像与治疗学

ABSTRACT

Objective To explore the enhancing effect of cyclic gadolinium chelates MRI contrast medium-Gatedotera of prostate hyperplasia. Methods: MRI manifestations of dynamic enhancing contrast (DEC) and delay enhancing findings of 75 patients with prostate hyperplasia in central zone were analyzed retrospectively. According to contrast medium, the patients were divided into 4 groups, including observed group (Gatedotera, n=20), control group 1 (Magnevist, n=15), control group 2 (Consun, n=16) and control group 3 (Omniscan, n=24). The basic and maximal signal intensities, enhancing degree, time to peak and rising slope of DEC curve of prostate hyperplasia nodes were compared among groups. Taken musculi obturator internus and imaging noise as references, the enhancing degree and CNR of parenchyma and capsule of hyperplasia nodes were obtained and compared among groups, and the displaying of capsule of each group was also analyzed. Results: Time to peak were significantly different among groups (F=3.812, P=0.014), of observe group was clearly shorter than of control group 2 (P=0.021), of control group 2 was clearly longer than of control group 1 (P=0.011) and control group 3 (P=0.023), respectively. The enhancing degrees and CNR of capsule were all statistical different among groups (all P0.05). Conclusion: The enhancing effect of cyclic gadolinium chelates was same as linear gadolinium chelates, while cyclic gadolinium chelates in capsule displaying was superior to linear gadolinium chelates.