Recent advances in G protein coupled receptor 119 agonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 2834-2842, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-862299
ABSTRACT
G protein-coupled receptor 119 (GPR119) has been a promising target for the treatment of type 2 diabetes. It can not only directly promote insulin secretion, but also indirectly increase insulin secretion by stimulating the release of glucose-dependent GIP/CLP-1 without causing hypoglycemia. The remarkable advantages of small molecule GPR119 agonists make it one of the research hotspots for the development of type 2 diabetes drugs. This article reviews the anti-diabetic small molecules based on the GPR119 target in the past five years.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2020
Tipo de documento:
Artigo
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