Analysis on 158 detainees with adverse reactions due to anti-infective drugs / 药学实践杂志

ABSTRACT

Objective To analyze the characteristics and trends of adverse drug reactions (ADR) induced by anti-infective drugs in Shanghai Prison General Hospital and provide a guideline of rational drug use and pharmacovigilance for detainees. Methods The anti-infective drug induced ADR cases reported to the national ADR monitoring center in our hospital from January 2011 to October 2018 were collected. The primary and secondary factors of types, organs and (or) systems affected by anti-infective drugs that lead to ADR were studied with Pareto diagram. Results 158 ADR cases caused by anti-infective drugs were collected. 143 cases (90.51%) were male in 20-59 years old. Pareto diagram analysis showed that ADRs mainly involved eight kinds of anti-infective drugs (antituberculosis drugs, cephalosporins, sulfonamides, antiviral drugs, penicillin, aminoglycosides, fluoroquinolones and nitroimidazoles). ADRs mainly involved in hepatobiliary and blood system. Both topical and systemic reactions were reported. Abnormal liver function, liver injury, rash and allergic reaction were the most common. Conclusion Pareto diagram method reflected the "critical minority and minor majority" analysis on detainees with ADRs caused by anti-infective drug. It was recommended to focus on anti-tuberculosis drugs and cephalosporin drugs to reduce or avoid the occurrence of ADR.