Current status and prospects in treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in adults / 白血病·淋巴瘤

ABSTRACT

The effect of traditional chemotherapy on Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) in adults is not satisfactory. With the introduction of tyrosine kinase inhibitor (TKI), the treatment paradigms and overall survival of adult patients with Ph + ALL have been improved. In the era of TKI, there is no consensus so far on the following issues, whether transplantation is still necessary, how to apply TKI before and after transplantation, what are the new advances in immunotherapy, and the effect of immunotherapy combined with targeted therapy. This article reviews the current treatment status and prospects in Ph + ALL.