Antisense oligonucleotide therapies in neurodegenerative disease / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 297-301, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-862986
ABSTRACT
Antisense oligonucleotides(ASOs)are small sequences of DNA or RNA able to target mRNA transcripts resulting in change or reduction in the expression of target genes, and became an emerging class of therapeutic drugs.With its high specific, adaptable, and low side effects, ASO drugs are widely used in rare diseases, tumor, inflammatory diseases, cardiovascular disease, and infectious diseases.Recent numerous advancements in ASO sequence design, chemical modifications and delivery methods, significant breakthroughs have been made in the treatment and ASOs become an ideal candidate therapies for neurodegenerative diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Journal of Pediatrics
Ano de publicação:
2020
Tipo de documento:
Artigo
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