Genetic susceptibility genes of childhood moyamoya disease / 国际儿科学杂志

ABSTRACT

Moyamoya disease(MMD) is a chronic progressive cerebrovascular disease characterized by progressive stenosis or occlusion of bilateral infernal of internal carotid artery, initial segments of anterior cerebral artery and middle cerebral artery and abnormal vascular network formation accompanied by compensatory hyperplasia of skull base.With the development of neuroimaging technology, the report of the disease has a rising trend year by year, the etiology and pathogenesis of MMD have not been clarified yet.Because of its racial susceptibility and familial aggregation, it is believed that genetic factors may be involved in the pathogenesis.This article mainly reviews the genetic related genes of MMD, aiming at understanding the role of genetic related genes in the occurrence and development of MMD in detail and comprehensively so as to make diagnosis earlier and more accurately, which is helpful for timely treatment and improvement of long-term prognosis for children.