Progress of cholestatic liver disease and intestinal flora in children / 国际儿科学杂志

ABSTRACT

Cholestatic liver disease is a major liver disease in children and an important cause of death and disability in children.In recent years, the incidence rate has increased.Multiple evidences show that the gut microbiota plays an important role in the pathogenesis of cholestatic liver disease by regulating metabolism and immune responses.However, the progression of the disease may also affect the composition of the gut microbiota, thereby exacerbating the progression of cholestasis.This article focuses on the correlation between intestinal microbes and cholestasis syndrome, and reviews its research progress in the pathogenesis and treatment of cholestatic liver disease.