Progress of pathogenesis of chronic active Epstein-Barr virus infection / 国际儿科学杂志

ABSTRACT

Chronic active Epstein-Barr virus(CAEBV)infection belongs to EBV positive T cell or NK cell lymphoproliferative diseases, which has an insidious onset, diverse clinical manifestations, rapid progression and poor prognosis.This article mainly reviews the research progress on the pathogenesis of CAEBV from four aspects how EBV infects T/NK cells, host genetic background, virus factors and cytokine pathway.