Role and mechanism of activating transcription factor 4 in cerebral ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 227-232, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-863092
ABSTRACT
Activating transcription factor 4 (ATF4) is a stress response factor containing a basic region-leucine zipper. When the body is under stress, the increased expression of ATF4 binds to cellular transcription factors, which in turn regulates the corresponding downstream target genes, thereby initiating cellular responses. After cerebral ischemia, ATF4 plays a neuroprotective role by participating in various pathophysiological processes such as regulating endoplasmic reticulum stress, oxidative stress, mitochondrial autophagy, inflammatory response, vascular regeneration, and synaptic plasticity. Therefore, ATF4 is expected to become a new target for the treatment of ischemic brain injury.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Journal of Cerebrovascular Diseases
Ano de publicação:
2020
Tipo de documento:
Artigo
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