Loss of Heterozygosity at 3p in Korean Non-Small Cell Lung Cancer / 결핵
Tuberculosis and Respiratory Diseases
;
: 975-983, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-86318
ABSTRACT
PURPOSE:
Frequent deletion of 3p in numerous cancer including lung cancer suggests the presence of tumor suppressor gene. 3p has been analysed by RFLP and PCR-LOH of microsatellite locus. In this study, we observed the deletion of 3p in Korean NSCLC by PCR-LOH of 4 microsatellite loci and investigated the clinical significance.Method:
62 surgically rejected NSCLC DNA and normal lung DNA have been analysed by PCR-LOH at three dinucleotide[D3S1228 (3p14.1-14.3), D3S1067 (3p14.3-21.1), D3S1029 (3p21.1-21.3)] and one tetranucleotide[D3S1537 (Sp 22-24.2)] repeat microsatellite loci.RESULTS:
Among 59 informative cases, 3p deletion by PCR-LOH at four microsatellite loci was found in 31 patients (52.5%). 3p deletion were found in 55% of squamous cell lung cancer and 47% of adenocarcinoma patients. No significant difference has been found in clinical parameters such as staging, smoking and survival according to the status of 3p deletion.CONCLUSION:
Deletions in 3p have played an important role in Korean NSCLC though no clinical significance was detected.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fumaça
/
Polimorfismo de Fragmento de Restrição
/
DNA
/
Adenocarcinoma
/
Fumar
/
Genes Supressores de Tumor
/
Carcinoma Pulmonar de Células não Pequenas
/
Repetições de Microssatélites
/
Perda de Heterozigosidade
/
Pulmão
Limite:
Humanos
Idioma:
Coreano
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
1998
Tipo de documento:
Artigo
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