Thromboxane in Pregnancy-Induced Hypertension / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1680-1683, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-86330
ABSTRACT
OBJECTIVE:
High thromboxane level evidence supports pivotal involvement of TxA2 in pathophysiology of pregnancy induced hypertension and provides a strong rationale for pursuing TxA2-blocking strategies in drug development.METHODS:
The stable metabolites of TXA2 (Thromboxane B2) in maternal blood of 12 patients with mild preeclampsia, 4 patients with severe preeclampsia and 14 normal parturients were measured by competitive enzyme immunoassay.RESULTS:
TxB2 concentrations were not increased in mild preeclampsia (101 +/- 12 pg/mL, n=12) as compared with normal pregnancy (150 +/- 15 pg/mL, n=14), but they were significantly increased in severe preeclampsia (454 +/- 102 pg/mL, p<0.0001, n=4).CONCLUSION:
Maternal plasma thromboxane is increased only in severe preeclampsia. Thus, increased thromboxane A2 biosynthesis correlates with disease severity and may have a pathogenetic role in pregnancy-induced hypertension. These findings provide a rationale for the use of aspirin in the treatment as well as in the prevention of this disorder.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Pré-Eclâmpsia
/
Tromboxano A2
/
Aspirina
/
Técnicas Imunoenzimáticas
/
Hipertensão Induzida pela Gravidez
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2004
Tipo de documento:
Artigo
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