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Glucose metabolism reprogramming during epithelial-mesenchymal transition in breast cancer / 国际外科学杂志
International Journal of Surgery ; (12): 350-356, 2020.
Artigo em Chinês | WPRIM | ID: wpr-863322
ABSTRACT
Invasion and metastasis are the leading causes of death from breast cancer. Epithelial-mesenchymal transition (EMT) can induce cancer metastasis by promoting tumor malignances and reprogramming tumor metabolism. As an important part of glucose metabolism, aerobic glycolysis not only provides sufficient energy for rapid growth of tumor cells, but also provides metastasis advantage for tumor cells by promoting the EMT process. In addition, the crosstalk network between glycolysis and EMT synergistically triggers cancer metastasis. Therefore, abnormal glucose metabolism and EMT play a key role in the occurrence and development of breast cancer metastasis, suggesting its clinical promise for the management of breast cancer metastasis.
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: International Journal of Surgery Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: International Journal of Surgery Ano de publicação: 2020 Tipo de documento: Artigo