Prognosis and related risk factors of distal cholangiocarcinoma after surgical treatment / 国际外科学杂志
International Journal of Surgery
;
(12): 369-373,f3, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-863337
ABSTRACT
Objective:
To evaluate the prognosis and related risk factors of distal cholangiocarcinoma after surgical treatment.Methods:
The clinical data of 123 patients of distal cholangiocarcinoma in Beijing Chaoyang Hospital between January 2011 and December 2019 were retrospectively analyzed, which including 72 males and 51 females, the average age was (64.9±9.2) years (range from 29 to 84 years). All patients underwent pancreatoduodenectomy. The observation measures contains (1) Perioperative outcomes; (2) Follow-up outcomes; (3) Risk factors for long-term survival of distal cholangiocarcinoma. Follow-up was carried out to understand the long-term survival of patients, and follow-up method contains the outpatient reexamination and telephone. The deadline of follow-up date was March 2020. The normal distribution data were expressed by ( Mean± SD), and the non-normal distribution data were expressed by M ( P25, P75). Count data were expressed by cases and percentage. Kaplan-Meier method was used to calculate and draw the survival curve. Log-rank test was used to compare the survival rate. Cox proportional risk model was used in multivariate factor analysis.Results:
(1) Perioperativeoutcomes:
In our research, all of 123 patients were successfully completed the operations, and 6 patients dead during the perioperative. (2) Follow-upoutcomes:
The incidence of postoperative complications was 27.6%(34/123). One hundred and twenty-one patients were followed up, the follow-up rate was 98.4%, and the median follow-up time was 41.0 months.The overall 1-year, 2-year, 3-year and 5-year survival rates were 71.8%, 50.5%, 35.5% and 30.2%. And the median survival time was 42.7 months. (3) Risk factors for long-term survival of distal cholangiocarcinoma Multivariate analysis showed that preoperative CA19-9 ( RR=1.470, 95% CI 1.028-2.101), portal venous system invasion ( RR=2.020, 95% CI 1.012-4.035) and tumor differentiation ( RR=1.735, 95% CI 1.195-2.520) were independent risk factors for the prognosis.Conclusions:
Radical pancreatoduodenectomy is the best treatment for distal cholangiocarcinoma. Preoperative CA19-9 level, portal venous system invasion and tumor differentiation are independent risk factors for the prognosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Chinês
Revista:
International Journal of Surgery
Ano de publicação:
2020
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS