Clinical study of self-made Runfu-Qufeng Decoction combined with conventional western medicine in the treatment of chronic eczema with blood deficiency and wind dryness syndrom / 国际中医中药杂志

ABSTRACT

Objective:To evaluate the clinical effect of self-made Runfu-Qufeng Decoction combined with conventional western medicine in the treatment of chronic eczema with blood deficiency and wind dryness syndrom. Methods:A total of 80 patients in our hospital from January 2017 to October 2018, who met the inclusion criteria, were selected and divided into two groups according to the random table method, 40 in each group. The control group was treated with conventional western medicine, while the research group was treated with self-made Runfu-Qufeng Decoction on the basis of control group. Both of the two groups were treated for 30 consecutive days with 3 months follow-up. The clinical symptom was scored before and after the treatment and the serum interleukin-4 (IL-4) as well asinterferon-γ (INF-γ) were detected by ELISA. The clinical efficacy was evaluated and the recurrence was recored. Results:The total effective rate of research group was 95.0% (38/40), while the control group was 80.0% (32/40). The difference between the two groups was statistically significant ( χ2=4.114, P=0.043). After the treatment, scores of pruritus degree, lesion area, rash morphology and total scores in the research group were significantly lower than those of the control group ( t values were 9.538, 4.383, 7.992, 4.094, all Ps<0.001). After the treatment, the serum IL-4 level (42.05 ± 3.84 ng/L vs. 47.29 ± 4.16 ng/L, t=5.854) of research group was significantly lower than that of the control group ( P<0.01), while the INF-γ (80.13 ± 7.10 ng/L vs. 74.04 ± 6.26ng/L, t=4.069) was significantly higher than that of the control group ( P<0.01). After 3 months of follow-up, the recurrence rate of the control group was 21.9% (7/32) and that of the research group was 2.6% (1/38). The difference between the two groups was statistically significant ( χ2=5.000, P=0.025). Conclusions:The self-made Runfu-Qufeng Decoction combined with conventional western medicine could relieve the clinical symptoms of patients with chronic eczema due to blood deficiency and wind dryness syndrom and improve the clinical efficacy.